The CHP responded to the scene at 1:30 a.m near the Highway 58 connector.
Officers said for unknown reasons, Felipe Mendoza,40, of Bakersfield, was driving northbound on I-5 when he went off the road and hit a guard rail.
Mendoza was ejected from the car. He was taken to Kern Medical Center with major injuries.
Officers said they suspect alcohol was a factor in the crash.
The investigation is ongoing.
A second accident happened due to the crash near the Ming Avenue exit.
One person was taken to the hospital with moderate injuries.
Mendoza was placed under arrest.
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